NAS Drive Compatibility

Compatible hard drives for Synology DS1621xs+

107 drives are on Synology's official compatibility list for the DS1621xs+. Read from synology.com, list refreshed 2026-11-03.

6-bay

Intel Xeon D-1527 · 4C/8T · DDR4 ECC SODIMM 8 GB · Broadwellnk

SYNOLOGY
CPUIntel Xeon D-1527 — 4 cores, 8 threads
Memory (as shipped)DDR4 ECC SODIMM 8 GB
PlatformBroadwellnk · x86_64 — package arch used by Synology's package center
Drive bays6 bays
107
Listed drives
36
NAS / Plus line
71
Enterprise line
24 TB
Largest listed drive

This model launched before 2025, so Synology's 2025 drive restrictions never applied — unlisted drives have always worked. The official list below is the vendor's tested matrix: the strongest compatibility signal, not a whitelist. Policy guide →

October 2026 — C3RB3R ransomware campaign. Is the DS1621xs+ at risk? Not by model — by DSM build. If this unit runs DSM below 7.4-90075 / 7.3.2-86009-4 / 7.2.2-72806-9 / 7.2.1-69057-12 (or any DSM 6.x), and its admin interface is reachable from the internet, it is exposed to the ongoing C3RB3R campaign. Check Control Panel → Info Center, update, then run the 12-step lockdown. Files already encrypted with .L0CK3D? Recovery guide — don't reboot first.

Capacity range on the official list

24TB (1) 20TB (3) 18TB (1) 16TB (6) 14TB (6) 12TB (13) 10TB (14) 10TB & below (63)

Where to start on the DS1621xs+

For a home or small-office workload, the NAS/Plus lines below balance sustained writes and RAID-rebuild tolerance. Enterprise speed is only worth paying for in full-bay builds:

Full DS1621xs+ compatibility list

Grouped by part number; Max shows the largest capacity Synology lists. Filter by brand, line or capacity:

DriveBrandSeriesLineTypeMax listed
HAT5320-24T Synology HAT5320 Enterprise 3.5" SATA HDD 24 TB
HAT3320-20T Synology HAT3320 Plus 3.5" SATA HDD 20 TB
HAT5310-20T Synology HAT5310 Enterprise 3.5" SATA HDD 20 TB
HAT5320-20T Synology HAT5320 Enterprise 3.5" SATA HDD 20 TB
HAT5310-18T Synology HAT5310 Enterprise 3.5" SATA HDD 18 TB
HAT3310-16T Synology HAT3310 Plus 3.5" SATA HDD 16 TB
HAT5300-16T Synology HAT5300 Enterprise 3.5" SATA HDD 16 TB
HAT5310-16T Synology HAT5310 Enterprise 3.5" SATA HDD 16 TB
MG08ACA16TE Toshiba MG08ACA*** Enterprise 3.5" SATA HDD 16 TB
ST16000NE000 - 2RW103 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 16 TB
ST16000NM001G - 2KK103 Seagate Exos X16 Enterprise 3.5" SATA HDD 16 TB
MG07ACA14TE Toshiba MG07ACA*** Enterprise 3.5" SATA HDD 14 TB
ST14000NE0008 - 2JK101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 14 TB
ST14000NE0008 - 2RX103 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 14 TB
ST14000NM0018 - 2H4101 Seagate Exos X14 Enterprise 3.5" SATA HDD 14 TB
ST14000NM001G - 2KJ103 Seagate Exos X16 Enterprise 3.5" SATA HDD 14 TB
WUH721414ALE6L4 - 0F31284 Western Digital Ultrastar DC HC530 Enterprise 3.5" SATA HDD 14 TB
HAT3300-12T Synology HAT3300 Plus 3.5" SATA HDD 12 TB
HAT3310-12T Synology HAT3310 Plus 3.5" SATA HDD 12 TB
HAT5300-12T Synology HAT5300 Enterprise 3.5" SATA HDD 12 TB
HUH721212ALE600 - 0F30144 Western Digital Ultrastar DC HC520 Enterprise 3.5" SATA HDD 12 TB
HUH721212ALE604 - 0F30146 Western Digital Ultrastar DC HC520 Enterprise 3.5" SATA HDD 12 TB
MG07ACA12TE Toshiba MG07ACA*** Enterprise 3.5" SATA HDD 12 TB
ST12000NE0007 - 2GT116 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 12 TB
ST12000NE0008 - 2JL101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 12 TB
ST12000NE0008 - 2PK103 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 12 TB
ST12000NM0008 Seagate Exos X14 Enterprise 3.5" SATA HDD 12 TB
ST12000NM001G - 2MV103 Seagate Exos X16 Enterprise 3.5" SATA HDD 12 TB
WD121KFBX Western Digital Red Pro Enterprise NAS 3.5" SATA HDD 12 TB
WD121KRYZ Western Digital Gold Enterprise 3.5" SATA HDD 12 TB
HUH721010ALE600 - 0F27452 Western Digital Ultrastar DC HC510 Enterprise 3.5" SATA HDD 10 TB
HUH721010ALE600 - 0F27604 Western Digital Ultrastar DC HC510 Enterprise 3.5" SATA HDD 10 TB
MG06ACA10TE Toshiba MG06ACA**** Enterprise 3.5" SATA HDD 10 TB
ST10000NE0004 - 1ZF101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 10 TB
ST10000NE0004 - 2GT11L Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 10 TB
ST10000NE0008 - 2JM101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 10 TB
ST10000NE0008 - 2PL103 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 10 TB
ST10000NM001G - 2MW103 Seagate Exos X16 Enterprise 3.5" SATA HDD 10 TB
ST10000NM0086 Seagate Exos X10 Enterprise 3.5" SATA HDD 10 TB
ST10000NM0478 Seagate Exos X14 Enterprise 3.5" SATA HDD 10 TB
WD101KFBX - 68R56N0 Western Digital Red Pro Enterprise NAS 3.5" SATA HDD 10 TB
WD102KFBX - 68M95N0 Western Digital Red Pro Enterprise NAS 3.5" SATA HDD 10 TB
WD102KRYZ Western Digital Gold Enterprise 3.5" SATA HDD 10 TB
WUS721010ALE6L4 Western Digital Ultrastar DC HC330 Enterprise 3.5" SATA HDD 10 TB
HAT3300-8T Synology HAT3300 Plus 3.5" SATA HDD 8 TB
HAT3310-8T Synology HAT3310 Plus 3.5" SATA HDD 8 TB
HAT3320-8T Synology HAT3320 Plus 3.5" SATA HDD 8 TB
HAT5300-8T Synology HAT5300 Enterprise 3.5" SATA HDD 8 TB
HAT5310-8T Synology HAT5310 Enterprise 3.5" SATA HDD 8 TB
HAT5320-8T Synology HAT5320 Enterprise 3.5" SATA HDD 8 TB
HUH721008ALE600 - 0F27455 Western Digital Ultrastar DC HC510 Enterprise 3.5" SATA HDD 8 TB
HUH721008ALE600 - 0F27610 Western Digital Ultrastar DC HC510 Enterprise 3.5" SATA HDD 8 TB
HUS728T8TALE6L4 Western Digital Ultrastar DC HC320 Enterprise 3.5" SATA HDD 8 TB
MG06ACA800E Toshiba MG06ACA**** Enterprise 3.5" SATA HDD 8 TB
ST8000NE0004 - 1ZF11G Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 8 TB
ST8000NE0008 - 2JN101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 8 TB
ST8000NE001 - 2M7101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 8 TB
ST8000NM000A - 2KE101 Seagate Exos 7E8 Enterprise 3.5" SATA HDD 8 TB
ST8000NM0206 Seagate Exos X10 Enterprise 3.5" SATA HDD 8 TB
WD8003FFBX - 68B9AN0 Western Digital Red Pro Enterprise NAS 3.5" SATA HDD 8 TB
WD8004FRYZ Western Digital Gold Enterprise 3.5" SATA HDD 8 TB
SAT5210-7000G Synology SAT5210 Enterprise 2.5" SATA SSD 7 TB
HAT3300-6T Synology HAT3300 Plus 3.5" SATA HDD 6 TB
MG06ACA600E Toshiba MG06ACA**** Enterprise 3.5" SATA HDD 6 TB
ST6000NE000 - 2KR101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 6 TB
ST6000NE0023 - 2EX110 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 6 TB
ST6000NM021A Seagate Exos 7E8 Enterprise 3.5" SATA HDD 6 TB
WD6003FFBX - 68MU3N0 Western Digital Red Pro Enterprise NAS 3.5" SATA HDD 6 TB
HAT3300-4T Synology HAT3300 Plus 3.5" SATA HDD 4 TB
HAT5300-4T Synology HAT5300 Enterprise 3.5" SATA HDD 4 TB
HAT5320-4T Synology HAT5320 Enterprise 3.5" SATA HDD 4 TB
MG04ACA400E Toshiba MG04ACA**** Enterprise 3.5" SATA HDD 4 TB
ST4000NE001 - 2MA101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 4 TB
ST4000NE0025 - 2EW107 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 4 TB
ST4000NM002A Seagate Exos 7E8 Enterprise 3.5" SATA HDD 4 TB
WD4003FFBX Western Digital Red Pro Enterprise NAS 3.5" SATA HDD 4 TB
SAT5200-3840G Synology SAT5200 Enterprise 2.5" SATA SSD 3.84 TB
SAT5210-3840G Synology SAT5210 Enterprise 2.5" SATA SSD 3.84 TB
SAT5220-3840G Synology SAT5220 Enterprise 2.5" SATA SSD 3.84 TB
SAT5221-3840G Synology SAT5221 Enterprise 2.5" SATA SSD 3.84 TB
MG04ACA300E Toshiba MG04ACA**** Enterprise 3.5" SATA HDD 3 TB
HAT3300-2T Synology HAT3300 Plus 3.5" SATA HDD 2 TB
HUS722T2TALA604 - 1W10002 Western Digital Ultrastar 7K2 Enterprise 3.5" SATA HDD 2 TB
MG04ACA200E Toshiba MG04ACA**** Enterprise 3.5" SATA HDD 2 TB
ST2000NE001 - 2M5101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 2 TB
ST2000NE0025 - 2FL101 Seagate IronWolf Pro Enterprise NAS 3.5" SATA HDD 2 TB
ST2000NM001A Seagate Exos 7E8 Enterprise 3.5" SATA HDD 2 TB
ST2000NX0253 - 1FM101 Seagate Exos 7E2000 Enterprise 2.5" SATA HDD 2 TB
WD2002FFSX - 68PF8N0 Western Digital Red Pro Enterprise NAS 3.5" SATA HDD 2 TB
WD2005FBYZ - 01YCBB0 Western Digital Gold Enterprise 3.5" SATA HDD 2 TB
WD2005VBYZ Western Digital Gold Enterprise 3.5" SATA HDD 2 TB
SAT5200-1920G Synology SAT5200 Enterprise 2.5" SATA SSD 1.92 TB
SAT5210-1920G Synology SAT5210 Enterprise 2.5" SATA SSD 1.92 TB
SAT5220-1920G Synology SAT5220 Enterprise 2.5" SATA SSD 1.92 TB
SAT5221-1920G Synology SAT5221 Enterprise 2.5" SATA SSD 1.92 TB
HUS722T1TALA604 - 1W10001 Western Digital Ultrastar 7K2 Enterprise 3.5" SATA HDD 1 TB
ST1000NX0313 Seagate Exos 7E2000 Enterprise 2.5" SATA HDD 1 TB
WD1005FBYZ - 01YCBB2 Western Digital Gold Enterprise 3.5" SATA HDD 1 TB
WD1005VBYZ Western Digital Gold Enterprise 3.5" SATA HDD 1 TB
SAT5200-960G Synology SAT5200 Enterprise 2.5" SATA SSD 960 GB
SAT5210-960G Synology SAT5210 Enterprise 2.5" SATA SSD 960 GB
SAT5220-960G Synology SAT5220 Enterprise 2.5" SATA SSD 960 GB
SAT5221-960G Synology SAT5221 Enterprise 2.5" SATA SSD 960 GB
SAT5200-480G Synology SAT5200 Enterprise 2.5" SATA SSD 480 GB
SAT5210-480G Synology SAT5210 Enterprise 2.5" SATA SSD 480 GB
SAT5220-480G Synology SAT5220 Enterprise 2.5" SATA SSD 480 GB
SAT5221-480G Synology SAT5221 Enterprise 2.5" SATA SSD 480 GB

Going big on the DS1621xs+?

At the top of the capacity range only enterprise lines are listed. They are built for sustained 7200RPM writes and 24/7 RAID duty — the right choice for a full-bay build: